Editorial overview: Mammalian hearing

Structural Overview Of Mammalian Zinc Metalloproteinases

Matrix metalloproteinases (MMP) are crucial for homeostasis (tissue remodelling and repair, bone growth, wound healing, etc.) and pathology (metastasis, angiogenesis, aneurysm rupture, etc.). Upregulated MMPs from macrophages are thus a two-edged sword, playing both defensive and aggressive roles. The related family of ADAMs (a disintegrin and a metalloproteinase) is sometimes overlooked becaus...

Editorial overview.

Editorial overview

Computational analysis tools and decision support systems have increased their penetration in the support of clinical processes and management of medical data and knowledge. Applications range from adjunct tools for diagnosis and disease investigation to the treatment and monitoring of therapeutic procedures. As all medical fields, the field of oncology is affected. This special issue includes ...

Overview of the epidemiologic research: Editorial Guidelines

Epidemiology can be considered as a very old science. For example, John Graunt, a statistician, published Natural and Political Observations. In the Bills of Mortality in 1662, he analyzed the mortality rolls in London before the Great Plague, presented one of the first life tables, and reported time trends for many diseases. He provided statist...

Editorial overview.

Richard Friesner works in a number of different areas of theoretical and computational chemistry, including methodology and software development, material science, and modeling of biological systems. His work in protein modeling is focused on high-resolution structural prediction and refinement, including loop prediction, side chain prediction, and protein–ligand docking and the prediction of b...